Annotation: The fuzzy model for generalized losses definition during pharmaceutical enterprises activity on the basis of indistinct sets theory methodology has been developed. It’s realization in MATLAB environment is executed. Common perspectivity for application of fuzzy-sets approaches for increase of the enterprises business safety level has been shown. The aim of the paper is to describe the method and computer’s realization for estimations of pharmaceutical enterprises safety level on drugs market in Ukraine. The main methodology is to use the fuzzy methods and Matlab’s fuzzy-tools for creation of multicriteria model for calculations of summary level of pharmaceutical wholesaler’s busines safety with financial, time, information, ecological and other losses as parametrs. On the basis of the conceptual approaches to study of busines safety and the computer fuzzy modeling methodology for industrial-administrative solutions and the fuzzy model for pharmaceutical enterprises busines safety level estimation has been created. The finded output surfaces allow to carry out at verbal level the analysis of association of an integral common from a modification of separate losses. On the basis this surfaces it is possible to know areas in which minor alterations of data-ins essentially change safety level of pharmaceutical enterprices.